A new publication named â€œIs the Discrimination of Subjective Cognitive Decline from Cognitively Healthy Adulthood and Mild Cognitive Impairment Possible? A Pilot Study Utilizing the R4Alz Batteryâ€ has been published in the Journal of Alzheimer’s Disease. The abstract of the publication follows:
Background:The early diagnosis of neurocognitive disorders before the symptomsâ€™ onset is the ultimate goal of the scientific community. REMEDES for Alzheimer (R4Alz) is a battery, designed for assessing cognitive control abilities in people with minor and major neurocognitive disorders. Objective:To investigate whether the R4Alz batteryâ€™s tasks differentiate subjective cognitive decline (SCD) from cognitively healthy adults (CHA) and mild cognitive impairment (MCI). Methods:The R4Alz battery was administered to 175 Greek adults, categorized in five groups a) healthy young adults (nâ€Š=â€Š42), b) healthy middle-aged adults (nâ€Š=â€Š33), c) healthy older adults (HOA; nâ€Š=â€Š14), d) community-dwelling older adults with SCD (nâ€Š=â€Š34), and e) people with MCI (nâ€Š=â€Š52). Results:Between the seven R4Alz subtasks, four showcased the best results for differentiating HOA from SCD: the working memory updating (WMCUT-S3), the inhibition and switching subtask (ICT/RST-S1&S2), the failure sets (FS) of the ICT/RST-S1&S2, and the cognitive flexibility subtask (ICT/RST-S3). The total score of the four R4Alz subtasks (R4AlzTot4) leads to an excellent discrimination among SCD and healthy adulthood, and to fare discrimination among SCD and MCI. Conclusion:The R4Alz battery is a novel approach regarding the neuropsychological assessment of people with SCD, since it can very well assist toward discriminating SCD from HOA. The R4Alz is able to measure decline of specific cognitive control abilitiesâ€”namely of working memory updating, and complex executive functionsâ€”which seem to be the neuropsychological substrate of cognitive complaints in community dwelling adults of advancing age.
You can read the full text in the link below.